What does this research mean for the field?

Microneedle-based transdermal drug delivery systems offer a versatile method to bypass the stratum corneum for administering various therapeutics, though significant obstacles remain before widespread market adoption. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To review the mechanisms, structural variations, and broad therapeutic applications of microneedle-based systems designed to overcome the skin's barrier properties.

September 5, 2026European Journal Pharmaceutical and Medical ResearchOpen Access

Microneedle-Based Drug Delivery Systems

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Authors

VJVrushali Santosh Gangurde2 Neha Kiran Johare*1

Discussion

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Overview

Narrative review reveals microneedle drug delivery mechanisms across diverse clinical therapies, highlighting their ability to bypass stratum corneum barriers.

Key Points

To review the mechanisms, structural variations, and broad therapeutic applications of microneedle-based systems designed to overcome the skin's barrier properties.
Synthesized literature on conventional transdermal drug delivery systems and their pharmacokinetic limitations.
Categorized microneedle engineering types, including solid, hollow, coated, dissolving, hydrogel-forming, and swellable formats.
Evaluated clinical application domains including vaccines, peptide delivery, oncology, and analgesia.
Microneedles breach the stratum corneum to create micron-sized conduits into the upper dermis or epidermis, bypassing hepatic first-pass metabolism without eliciting standard needle pain.
Structural variations allow the delivery of diverse payloads ranging from small-molecule lidocaine to complex macromolecules, oligonucleotides, and vaccines.
Despite expanding commercial translation across oncology, ophthalmology, and cosmetics, widespread adoption requires addressing key manufacturing and regulatory hurdles.

Cite This Study

Vrushali Santosh Gangurde2 Neha Kiran Johare*1 (2026) studied this question.

synapsesocial.com/papers/6a9bd4726b95aff0620ec322 https://doi.org/10.5281/zenodo.22268200

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September 5, 2026European Journal Pharmaceutical and Medical ResearchOpen Access

Microneedle-Based Drug Delivery Systems

View Full Paper

Ask AI

Bookmark

Authors

VJVrushali Santosh Gangurde2 Neha Kiran Johare*1

Discussion

Member takes

Overview

Narrative review reveals microneedle drug delivery mechanisms across diverse clinical therapies, highlighting their ability to bypass stratum corneum barriers.

Key Points

To review the mechanisms, structural variations, and broad therapeutic applications of microneedle-based systems designed to overcome the skin's barrier properties.
Synthesized literature on conventional transdermal drug delivery systems and their pharmacokinetic limitations.
Categorized microneedle engineering types, including solid, hollow, coated, dissolving, hydrogel-forming, and swellable formats.
Evaluated clinical application domains including vaccines, peptide delivery, oncology, and analgesia.
Microneedles breach the stratum corneum to create micron-sized conduits into the upper dermis or epidermis, bypassing hepatic first-pass metabolism without eliciting standard needle pain.
Structural variations allow the delivery of diverse payloads ranging from small-molecule lidocaine to complex macromolecules, oligonucleotides, and vaccines.
Despite expanding commercial translation across oncology, ophthalmology, and cosmetics, widespread adoption requires addressing key manufacturing and regulatory hurdles.

Cite This Study

Vrushali Santosh Gangurde2 Neha Kiran Johare*1 (2026) studied this question.

synapsesocial.com/papers/6a9bd4726b95aff0620ec322 https://doi.org/10.5281/zenodo.22268200

Also Consider

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