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September 5, 2026Infectious Diseases of PovertyOpen Access

Climate change reshapes the potential transmission risk of human alveolar and cystic echinococcosis in western China: a projection based on MaxEnt models

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Authors

XWXu WangQGQuzhen GongsangSYShijie Yang

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Overview

Ecological modeling study projects shifting and expanding transmission risks of alveolar and cystic echinococcosis in human populations, highlighting the need for targeted disease surveillance.

Key Points

  • To model the ecological niches of Echinococcus multilocularis and Echinococcus granulosus sensu lato and project the influence of climate change on future disease transmission geography.
  • Trained optimized Maximum Entropy (MaxEnt) models using 1,247 georeferenced human cases diagnosed between 1981 and 2016 in western China and contemporary bioclimatic variables.
  • Evaluated model accuracy using Area Under the Curve (AUC) and partial ROC AUC (AUCpROC), validating results against county-level incidence.
  • Projected parasite habitat suitability across multiple periods from 2011 to 2100 under three climate pathways (SSP-126, SSP-370, SSP-585) using five global climate models.
  • Models demonstrated high accuracy (AUC > 0.92; AUCpROC: 0.084 for E. multilocularis, 0.070 for E. granulosus) and correlated significantly with county-level incidence (ρ > 0.6, P < 0.0001).
  • Echinococcus multilocularis suitable habitats shift toward higher altitudes, expanding in Qinghai and Xizang while contracting in lower-altitude areas of Ningxia and Gansu.
  • Echinococcus granulosus exhibits extensive outward expansion from endemic margins across the Tibetan Plateau, identifying Qinghai and Xizang as primary expansion hotspots for both parasite species.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd48c6b95aff0620ec4c7https://doi.org/10.1186/s40249-026-01482-1
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