Key result
Sugammadex administration transiently increased prothrombin time (MD 1.42) compared to control, but did not significantly affect activated partial thromboplastin time or increase the risk of postoperative bleeding.
Why the study?
Sugammadex rapidly reverses rocuronium-induced neuromuscular blockade, but may prolong coagulation time and influence postoperative bleeding.
Does sugammadex prolong coagulation time and influence postoperative bleeding in adults?
Comparison
Sugammadex vs control
Design
Systematic review and meta-analysis of RCTs
Authors
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PT prolongation with sugammadex does not support routine coagulation monitoring in healthy adults; extends meta-analytic evidence on hemostatic safety.
Meta-Analysis (n=1,328)
Does sugammadex prolong coagulation time and influence postoperative bleeding in adults?
Mean Difference: 1.42 (95% CI 0.28–2.56)
Sugammadex administration transiently increases PT values without affecting APTT, suggesting routine coagulation monitoring is not required in healthy individuals.
Tsai et al. (2025) conducted a meta-analysis in Neuromuscular blockade reversal (n=1,328). Sugammadex vs. Anticholinesterase agents or placebo was evaluated on Change in prothrombin time (PT/INR) (MD 1.42, 95% CI 0.28-2.56). Sugammadex administration transiently increased prothrombin time (MD 1.42) compared to control, but did not significantly affect activated partial thromboplastin time or increase the risk of postoperative bleeding.
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