Key result
NOACs showed similar efficacy for VTE or VTE-related deaths compared with LMWH in elderly postarthroplasty patients (OR 0.62; 95% CI 0.30-1.26; P=0.18) but significantly lower bleeding risk.
Why the study?
Do NOACs reduce VTE or bleeding compared to LMWH in elderly patients undergoing elective postarthroplasty?
Meta-Analysis (n=29,403)
Yes
Do NOACs reduce VTE or bleeding compared to LMWH in elderly patients undergoing elective postarthroplasty?
Odds Ratio: 0.62 (95% CI 0.3–1.26)
p-value: p=0.18
In elderly patients undergoing elective postarthroplasty, NOACs offer similar efficacy for VTE prophylaxis but superior safety regarding bleeding compared to LMWH.
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Supports preferring NOACs over LMWH for VTE prophylaxis in elderly postarthroplasty patients; extends safety evidence to this high-risk group.
Pathak et al. (2015) conducted a meta-analysis in Venous thromboembolism in elective postarthroplasty (n=29,403). New oral anticoagulants (NOACs) vs. Low-molecular-weight heparin (LMWH) was evaluated on VTE or VTE-related deaths (OR 0.62, 95% CI 0.30-1.26, p=0.18). NOACs showed similar efficacy for VTE or VTE-related deaths compared with LMWH in elderly postarthroplasty patients (OR 0.62; 95% CI 0.30-1.26; P=0.18) but significantly lower bleeding risk.
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