Key result
In a cohort of 37 pediatric patients with hypertensive crisis, oral nifedipine (62.1%) and intravenous labetalol (21.6%) were the most frequently used initial treatments, with no reported mortalities or major morbidities.
Why the study?
Most children presenting with hypertensive crisis have a secondary cause, prompting this study to describe the epidemiology and management of pediatric hypertensive crisis.
What are the common causes and effective treatments for hypertensive crisis in children?
Cohort (n=37)
No
What are the common causes and effective treatments for hypertensive crisis in children?
Hypertensive crisis in children is predominantly secondary to renal pathology and can be safely and effectively managed with oral nifedipine or intravenous labetalol.
Supports nifedipine and labetalol as common initial agents in pediatric hypertensive crisis; leaves open need for randomized trials to guide practice.
Most children who present with hypertensive crisis have a secondary cause for hypertension. This study describes the epidemiology and management of children with hypertensive crisis. A retrospective cohort study was done in a tertiary pediatric hospital from 2009 to 2015. Thirty-seven patients were treated for hypertensive crisis. Twelve (32.4%) patients were treated for hypertensive emergency. The majority of our patients (33 [89.1%]) had a secondary cause of hypertension. The most common identifiable cause of hypertension was a renal pathology (18/37 [48.6%]). Oral nifedipine (23 [62.1%]) was the most frequently used antihypertensive, followed by intravenous labetalol (8 [21.6%]). There were no mortalities or morbidities. Hypertensive crisis in children is likely secondary in nature. Oral nifedipine and intravenous labetalol are both effective treatments.
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Lim et al. (2019) conducted a cohort in Hypertensive crisis (n=37). Antihypertensive treatment (oral nifedipine, intravenous labetalol) was evaluated on Immediate treatment administered in hypertensive crisis. In a cohort of 37 pediatric patients with hypertensive crisis, oral nifedipine (62.1%) and intravenous labetalol (21.6%) were the most frequently used initial treatments, with no reported mortalities or major morbidities.
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