Key result
The Naughton treadmill protocol with a 1/8 updating factor demonstrated significantly lower noise and higher TWA confirmation rates compared to the Ellestad protocol, indicating its viability for simultaneous stress testing and TWA measurement.
Why the study?
Tools are needed to identify individuals susceptible to sudden cardiac death, leading to this evaluation of the modified moving average methodology to obtain microvolt T-wave alternans using specific treadmill protocols.
Does the Naughton protocol with 1/8 updating factor improve the measurement of microvolt T-wave alternans compared to the Ellestad protocol during treadmill stress testing?
Observational (n=539)
No
Does the Naughton protocol with 1/8 updating factor improve the measurement of microvolt T-wave alternans compared to the Ellestad protocol during treadmill stress testing?
The Naughton protocol with a 1/8 updating factor is viable for simultaneous performance of stress testing and measurement of T-wave alternans, presenting lower noise and greater confirmation than the Ellestad protocol.
Supports Naughton protocol for combined stress-TWA testing; leaves open randomized validation before wider use.
Sudden cardiac death is impactful. There has been an increase in the search for tools capable of identifying individuals who are most susceptible, such as the microvolt T-wave alternans. This study aims to analyze the applicability of the modified moving average methodology to obtain the microvolt T-wave alternans using treadmill specific protocols. Medical records of patients during the period August 2006-December 2014 were retrospectively analyzed. Five hundred and thirty nine exams were then included, divided into groups according to the protocol and updating factor used: Ellestad factor 8 or 32, Naughton factor 8 or 32. The topics for analysis were the alternans behavior, noise and confirmation according to the groups of leads analyzed (frontal, transversal and orthogonal planes). The greater microvolt T-wave alternans was found during the stress phase in most of the tests. Group Naughton 8 presented lower noise in this phase for the transverse and orthogonal planes (p = 0.0082 and p < 0.0001), with greater confirmation of frontal and orthogonal planes in comparison with group Ellestad 8 (p = 0.0002 and 0.0008). The results indicate the viability of simultaneous performance of the stress test and measurement of the T wave alternans with Naughton protocol with 1/8 updating factor.
No takes yet. Share an insight, caveat, or question.
Filho et al. (2022) conducted an observational in Patients undergoing treadmill stress testing (n=539). Naughton protocol with 1/8 updating factor vs. Ellestad protocol with 1/8 updating factor was evaluated on TWA confirmation rate in frontal leads during maximum TWA moment (p=0.0002). The Naughton treadmill protocol with a 1/8 updating factor demonstrated significantly lower noise and higher TWA confirmation rates compared to the Ellestad protocol, indicating its viability for simultaneous stress testing and TWA measurement.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: