Chitosan was covalently coupled to type I collagen by using 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide in morpholinoethane sulfonic acid buffer. The physico-chemical characteristics of the collagen/chitosan matrices (CCM) were evaluated by electron spectroscopy and tensile mechanical strength. The platelet deposition and endothelial cell culture experiments showed that the CCM have good cell compatibility and excellent blood compatibility. The results suggest that the CCM creates an appropriate environment for the regeneration of endothelial cells and are promising candidates as biomaterials for the tissue regeneration scaffolds.
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Wang et al. (2003) studied this question.
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