Key result
The magnitude of weight loss 9 months after bariatric surgery did not correlate with improvements in cardiometabolic risk factors, as no significant differences were found across weight loss tertiles (P > 0.05).
Why the study?
This study investigated whether the degree of weight loss properly reflects improvements in cardiometabolic health among patients who underwent Roux-en-Y gastric bypass.
Does the magnitude of weight loss following Roux-en-Y gastric bypass correlate with improvements in cardiometabolic risk factors in women with obesity?
Observational (n=42)
No
Does the magnitude of weight loss following Roux-en-Y gastric bypass correlate with improvements in cardiometabolic risk factors in women with obesity?
p-value: p=>0.05
The magnitude of weight loss following bariatric surgery does not correlate with the degree of improvement in cardiovascular risk factors, suggesting weight loss alone is insufficient to assess cardiometabolic success.
May not uniformly track cardiometabolic gains across weight-loss tertiles after RYGB; leaves open need for individualized metrics beyond weight alone.
PURPOSE: The aim of this exploratory study was to investigate whether the degree of weight loss properly reflects improvements in cardiometabolic health among patients who underwent Roux-en-Y gastric bypass. METHODS: In this ancillary analysis from a clinical trial, patients were clustered into tertiles according to the magnitude of the percentage weight loss (1st tertile: "higher weight loss": -37.1 ± 5.8%; 2nd tertile: "moderate weight loss": -29.7 ± 1.4%; 3rd tertile: "lower weight loss": -24.2 ± 2.3%). Delta changes (9 months after surgery-baseline) in clustered cardiometabolic risk (i.e., blood pressure index, fasting glucose, high-density lipoprotein [HDL] and triglycerides [TG]), glycated hemoglobin (HbA1c), homeostasis model assessment (HOMA-IR), and C-reactive protein (CRP) were calculated. RESULTS: > 0.05 for all). Individual variable analysis confirmed cardiometabolic improvements across the spectrum on weight-loss. There were no associations between weight loss and any dependent variable. CONCLUSION: Weight loss following bariatric surgery does not correlate with improvements in cardiovascular risk factors. These findings suggest that weight loss alone may be insufficient to assess the cardiometabolic success of bariatric surgery, and the search for alternate proxies that better predict surgery success are needed.
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Gil et al. (2021) conducted an observational in Morbid obesity (n=42). Magnitude of percentage weight loss vs. Comparisons across weight loss tertiles (higher vs moderate vs lower) was evaluated on Delta changes (9 months after surgery-baseline) in clustered cardiometabolic risk score and individual risk factors (fasting glucose, HbA1c, HOMA-IR, blood pressure index, CRP, HDL, TG) (p=>0.05). The magnitude of weight loss 9 months after bariatric surgery did not correlate with improvements in cardiometabolic risk factors, as no significant differences were found across weight loss tertiles (P > 0.05).
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