The inhibitory action of imipramine and some analogues on the uptake of 5-hydroxytryptamine by human blood platelets in vitro was investigated. In concentrations comparable with those reached in plasma during therapy, imipramine and the isosteric compound, amitriptyline, were more effective than their metabolites. Chlorpromazine was less effective than the latter and orphenadrine ineffective at the concentrations tested.
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Yates et al. (1964) studied this question.
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