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The interest of 5-hydroxytryptamine (5HT) for psychiatry arose originally from Gaddum's (8, 9) observation that its peripheral pharmacological actions were antagonized in a highly specific manner by a low concentration of lysergic acid diethylamide (LSD). This led to the hypothesis that the hallucinogenic action of LSD was due to its antagonism to 5HT in the central nervous system (Woolley and Shaw, 21; Gaddum, 7). However, Cerletti and Rothlin (5) subsequently found that brom-LSD, which is not a hallucinogen, was an equally potent antagonist of the peripheral actions of 5HT.
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Todrick et al. (1960) studied this question.
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