Key result
Multimodal perioperative analgesia significantly reduced the incidence of mild and moderate postoperative cognitive impairment compared to traditional anesthesia (16.3% vs 69.0%, p=0.007).
Why the study?
Approaches to effective perioperative pain management, including the prevention of postoperative cognitive dysfunction, remain controversial.
Does multimodal perioperative analgesia reduce postoperative pain and cognitive dysfunction in patients undergoing surgery for degenerative lumbar spine diseases?
Cohort (n=85)
Does multimodal perioperative analgesia reduce postoperative pain and cognitive dysfunction in patients undergoing surgery for degenerative lumbar spine diseases?
Multimodal perioperative analgesia significantly improves postoperative pain control and reduces cognitive dysfunction in patients undergoing lumbar spine surgery.
Hypothesis-generating for complex perioperative analgesia in lumbar spine surgery; larger trials needed to confirm cognitive effects.
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Byvaltsev et al. (2020) conducted a cohort in Degenerative lumbar spine diseases (n=85). Multimodal perioperative analgesia (preoperative ketoprofen, intraoperative dexmedetomidine, postoperative paracetamol, and wound infiltration with ropivacaine) vs. Traditional anesthesia was evaluated on Mild and moderate cognitive impairment (p=0.007). Multimodal perioperative analgesia significantly reduced the incidence of mild and moderate postoperative cognitive impairment compared to traditional anesthesia (16.3% vs 69.0%, p=0.007).
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