Key result
The alpha1B amino terminus contains determinants for beta subunit-mediated voltage-dependent inactivation properties in Ca2+ channels.
The amino terminus of the alpha1B Ca2+ channel plays a crucial role in mediating the voltage-dependent inactivation properties conferred by auxiliary beta subunits.
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Identifies structural determinants of Ca2+ channel inactivation; extends molecular models but remains hypothesis-generating for native physiology.
Stephens et al. (2000) studied this question. Co-expression of auxiliary beta subunits with the alpha1B Ca2+ channel subunit vs. alpha1B alone was evaluated on Voltage-dependent inactivation properties. The alpha1B amino terminus contains determinants for beta subunit-mediated voltage-dependent inactivation properties in Ca2+ channels.
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