Key result
Chronic kidney disease was associated with higher odds for vibration detection threshold (OR 1.7; 95% CI 1.1-2.7) and abnormal heart rate response (OR 1.6; 95% CI 1.1-2.2) compared to non-CKD.
Why the study?
Is early chronic kidney disease associated with altered sensory, motor, and autonomic nerve function in older adults?
Cohort (n=2,290)
Is early chronic kidney disease associated with altered sensory, motor, and autonomic nerve function in older adults?
Odds Ratio: 1.7 (95% CI 1.1–2.7)
Early chronic kidney disease is independently associated with sensory and autonomic nerve dysfunction in older adults, even after adjusting for comorbidities like diabetes.
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Early CKD was associated with altered nerve function; leaves open its role in mobility decline and requires prospective confirmation.
Moorthi et al. (2018) conducted a cohort in Chronic kidney disease (n=2,290). Chronic kidney disease (eGFR ≤60 mL/min/1.73 m2) vs. Non-CKD (eGFR >60 mL/min/1.73 m2) was evaluated on Vibration detection threshold (OR 1.7, 95% CI 1.1-2.7). Chronic kidney disease was associated with higher odds for vibration detection threshold (OR 1.7; 95% CI 1.1-2.7) and abnormal heart rate response (OR 1.6; 95% CI 1.1-2.2) compared to non-CKD.
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