Key result
Thiopentone is the intravenous induction agent most commonly associated with severe adverse reactions (76%), particularly when used with suxamethonium.
Thiopentone remains the most common intravenous induction agent associated with severe adverse reactions reported to an advisory service.
May warrant caution with thiopentone-suxamethonium induction; leaves open true incidence versus reporting bias in advisory data.
The continued work of the advisory service is reported; this now amounts to at least 300 enquiries about clinically severe adverse reactions each year. Thiopentone is still the most commonly associated intravenous induction agent with adverse reactions (76%), particularly when it is used with suxamethonium. Local anaesthetics account for between 5 and 10% reports.
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J. Watkins (1989) studied this question. Thiopentone is the intravenous induction agent most commonly associated with severe adverse reactions (76%), particularly when used with suxamethonium.
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