Key result
Age ≥80 years was associated with significantly worse postoperative outcomes across multiple major surgeries, including a 3.99-fold higher risk of 30-day mortality after colon cancer surgery.
Why the study?
With an aging global population, postoperative outcomes may be worse in elderly patients, but trends in major surgical resections and outcomes in octogenarians needed nationwide evaluation.
Does age ≥80 years worsen postoperative outcomes in patients undergoing major surgical procedures?
Cohort (n=90,654)
Yes
Does age ≥80 years worsen postoperative outcomes in patients undergoing major surgical procedures?
Relative Risk: 3.99
Absolute Event Rate: 5.8% vs 1.5%
p-value: p=<0.001
Octogenarians undergoing major surgical procedures have significantly worse 30-day morbidity and mortality compared to younger patients, highlighting the need for careful patient selection and prehabilitation.
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Stable resection rates with worse outcomes in octogenarians warrant cautious selection; leaves open optimal thresholds for major surgery in the elderly.
Elfrink et al. (2022) conducted a cohort in Major surgical procedures (oncological and abdominal aortic aneurysm) (n=90,654). Age ≥ 80 years (octogenarians) vs. Age < 80 years was evaluated on 30-day mortality (colon cancer cohort) (RR 3.99, p=<0.001). Age ≥80 years was associated with significantly worse postoperative outcomes across multiple major surgeries, including a 3.99-fold higher risk of 30-day mortality after colon cancer surgery.
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