Key result
Sinusoidal blood flow induces anisotropic electrical and optical properties, with longitudinal resistivity changes opposite to transverse changes and delayed minimum points relative to zero flow.
Flowing blood exhibits anisotropic electrical and optical properties due to red blood cell orientation and deformation, with viscosity decreasing at higher flow amplitudes and frequencies.
Suggests caution in bioimpedance monitoring during pulsatile flow; leaves open translation of RBC anisotropy from animal models to humans.
The changes of viscosity, optical reflection and electrical resistivity of blood due to flow are dependent on the orientation and deformation of red cells. From electrical point of view, it can be assumed that blood is suspension of small insulating particles (red cells) in conductive fluid (plasma) when the frequency of supplied voltage is lower than several hundreds KHz. When blood flows, red cells deform and orient in flow direction. Therefore, flowing blood shows anisotropic electrical and optical properties. In steady flow, blood resistivity longitudinal to flow decrease with flow rate, and transverse one increases. Blood flow in living body is not steady but pulsatile. We measured both longitudinal and transverse resistivity changes, optical reflection change and viscosity change of sinusoidally flowing blood in a rectangular conduit. The results are 1) during one period of sinusoidal flow the longitudinal resistivity change is opposite to that of transverse one, 2) the waveform of reflection light change is similar to that of resistance change, and 3) minimum points of both longitudinal resistivity and viscosity changes do not appear at the moment when flow is zero but are delayed. When the amplitude of sinusoidal flow is small and oscillation frequency is high, the phase difference between the zero crossing period of flow and the period of minimum change in resistivity, increases up to 90 degrees. Viscosity of blood decreases with increase of amplitude and frequency of sinusoidal flow.
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Ninomiya et al. (1988) studied this question. Sinusoidal flow vs. Steady flow was evaluated on Changes in longitudinal and transverse resistivity, optical reflection, and viscosity. Sinusoidal blood flow induces anisotropic electrical and optical properties, with longitudinal resistivity changes opposite to transverse changes and delayed minimum points relative to zero flow.
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