Key result
Administration of ANGPTL8 reduced weight gain, improved glucose tolerance, and attenuated adipose tissue inflammation through regulation of macrophage polarization in diet-induced obese mice.
Why the study?
Does ANGPTL8 administration improve insulin resistance and attenuate adipose tissue inflammation in diet-induced obese mice?
Population
Diet-induced obese mice and cultured peritoneal macrophage line
Design
Preclinical
Authors
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May inform ANGPTL8-targeted therapies; leaves open translation to human obesity or diabetes.
Does ANGPTL8 administration improve insulin resistance and attenuate adipose tissue inflammation in diet-induced obese mice?
ANGPTL8 administration attenuates adipose tissue inflammation through regulation of macrophage polarization, suggesting a potential therapeutic role in improving insulin resistance.
Luo et al. (2018) studied Diet-induced obesity and insulin resistance. Angiopoietin-like 8 (ANGPTL8) was evaluated on Weight gain, glucose tolerance, and adipose tissue inflammation. Administration of ANGPTL8 reduced weight gain, improved glucose tolerance, and attenuated adipose tissue inflammation through regulation of macrophage polarization in diet-induced obese mice.
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