Key result
Among patients with lung, gastric, pancreatic cancers, or lymphoma, VTE incidence was 4.4% (36.3 per 1000 patient-years), with low BMI, anemia, and short aPTT identified as novel risk factors.
Why the study?
Prior studies reported cancer-associated VTE incidence in Taiwan was much lower than in Western countries and lower than anecdotal observations, prompting a detailed investigation into local incidence and risk factors.
Cohort (n=5,620)
No
The incidence of cancer-associated VTE in Taiwan is higher than previously reported, and novel risk factors such as low BMI and short aPTT were identified.
Higher cancer-associated VTE incidence in Taiwan than prior reports warrants vigilance in high-risk cancers; leaves open whether rates approach Western benchmarks or reflect detection differences.
BACKGROUND: Cancer-associated venous thromboembolism (VTE) is a distinct pathological entity with much higher incidence and unique risk factors compared to general VTE. A previous study reported that cancer associated-VTE incidence in Taiwan is much lower than that reported for western countries and also lower than our anecdotal observations. To address this issue further, we initiated an investigation locally using a more detailed approach than used previously with comprehensive review of medical records to gain new insight into the incidence and risk factors for cancer-associated VTE. METHODS: Medical records of all adult patients with lung, pancreatic and gastric cancers, and lymphoma diagnosed from January 2011 to December 2013 in National Taiwan University Hospital indexed through the local cancer registry database were reviewed. VTE patients were identified through diagnosis coding and comprehensive medical chart review. RESULTS: Among 5620 consecutive lung, gastric and pancreatic cancer, and lymphoma patients, VTE was diagnosed in 246 (4.4%). Overall VTE incidence was 36.3 per 1000 patient-year. Multivariate analysis showed that not only high but also low body mass index (BMI) was associated with VTE risk with different cutoff levels by gender. Mildly to moderately anemic patients were at higher risk of VTE. Activated partial thromboplastin time (aPTT) had proportionally and reversely correlation to VTE risk. CONCLUSION: We reported higher incidence of cancer associated VTE in Taiwan. Low BMI and short aPTT were found to be related to higher VTE risk that was not reported before.
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Chou et al. (2021) conducted a cohort in Lung, gastric, pancreatic cancers or lymphoma (n=5,620). Risk factors (BMI, anemia, aPTT) was evaluated on Venous thromboembolism (VTE). Among patients with lung, gastric, pancreatic cancers, or lymphoma, VTE incidence was 4.4% (36.3 per 1000 patient-years), with low BMI, anemia, and short aPTT identified as novel risk factors.
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