A high-yielding method was developed for the preparation of ingenol 3-angelate (PEP005, ingenol mebutate) via the corresponding 5,20-acetonide without concomitant isomerization of the angelate ( Z -form) to the corresponding tiglate ( E -form). The general scope of the stereoconservative esterification method was further evaluated on several different alcohols, giving the angelates in up to quantitative yield without isomerization to the tiglate.
No takes yet. Share an insight, caveat, or question.
Liang et al. (2012) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: