Key result
Infection with the Trypanosoma cruzi TcII genotype was strongly associated with severe chronic Chagas cardiomyopathy compared to other genotypes (adjusted OR 1450.96).
Why the study?
The association between Trypanosoma cruzi genetic variability and the clinical forms of Chagas disease has not been fully elucidated.
Cross-Sectional (n=175)
Odds Ratio: 1450.96 (95% CI 146.29–14391.32)
Absolute Event Rate: 92.2% vs 0%
p-value: p=<0.0001
In patients with chronic Chagas cardiomyopathy, infection with the Trypanosoma cruzi TcII genotype is strongly correlated with severe left ventricular systolic dysfunction.
DTU diversity observed in chronic cardiac ChD; leaves open whether specific lineages influence severity or treatment response.
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Oliveira et al. (2022) conducted a cross-sectional in Chronic Chagas cardiomyopathy (n=175). Trypanosoma cruzi TcII discrete typing unit (DTU) vs. Other Trypanosoma cruzi DTUs (TcI, TcIII, TcIV, TcV, TcVI, and mixed) was evaluated on Severe chronic Chagas cardiomyopathy (LVEF ≤ 39%) (OR 1450.96, 95% CI 146.29-14391.32, p=<0.0001). Infection with the Trypanosoma cruzi TcII genotype was strongly associated with severe chronic Chagas cardiomyopathy compared to other genotypes (adjusted OR 1450.96).
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