Key result
ACh-induced EDHF-type relaxation was significantly weaker in STZ-induced diabetic rats than in controls, likely due to a reduction in cAMP action via increased PDE3 activity.
Population
Isolated superior mesenteric artery rings from streptozotocin-induced diabetic rats and age-matched control…
Comparison
Assessment of ACh-induced EDHF-type relaxation… vs Age-matched control rats
Design
Preclinical
Authors
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May implicate PDE3 inhibition as a target in diabetic endothelial dysfunction; leaves open translation to human disease.
Impairment of EDHF-type relaxations in diabetic rats may be driven by reduced cAMP action due to increased PDE3 activity.
Matsumoto et al. (2003) studied Diabetes. STZ-induced diabetes vs. Age-matched control rats was evaluated on ACh-induced EDHF-type relaxation and phosphodiesterase (PDE) expression. ACh-induced EDHF-type relaxation was significantly weaker in STZ-induced diabetic rats than in controls, likely due to a reduction in cAMP action via increased PDE3 activity.
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