Key result
Prolonged oral propranolol (320 mg daily) induced more complete beta blockade during exercise than acute intravenous propranolol, resulting in a slower cardiac rate.
Why the study?
Does prolonged oral propranolol provide more complete beta blockade during exercise compared to acute intravenous propranolol in normal male subjects?
Population
5 normal male subjects
Comparison
Prolonged oral propranolol and atropine vs Acute intravenous propranolol and atropine
Design
Other
Authors
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Standard IV propranolol dosing may fail to achieve full exercise beta blockade; leaves open optimal regimens for research or clinical use.
Does prolonged oral propranolol provide more complete beta blockade during exercise compared to acute intravenous propranolol in normal male subjects?
The standard intravenous dose of propranolol used to achieve a pharmacologically isolated heart at rest is insufficient to induce full beta blockade during exercise compared to prolonged oral administration.
Sutton et al. (1977) studied Healthy (n=5). Oral propranolol vs. Intravenous propranolol was evaluated on Intrinsic sinoatrial (SA) rate at rest and during exercise. Prolonged oral propranolol (320 mg daily) induced more complete beta blockade during exercise than acute intravenous propranolol, resulting in a slower cardiac rate.
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