Key result
Cefotetan administration followed by ethanol ingestion caused significant facial flushing in 62.5% of healthy male volunteers compared to 0% with placebo, indicating a risk for disulfiram-type reactions.
Why the study?
Does cefotetan induce disulfiram-type reactions and hypoprothrombinemia when combined with ethanol in healthy male volunteers?
Population
8 healthy male volunteers
Comparison
Cefotetan 2 g administered at 12-h intervals for… vs Placebo administered at 12-h intervals for three…
Design
RCT, double-blind
Authors
Loading...
Cefotetan warrants ethanol avoidance counseling; RCT confirms disulfiram-type reaction risk in volunteers.
RCT (n=8)
Double-blind
Randomly assigned
No
Does cefotetan induce disulfiram-type reactions and hypoprothrombinemia when combined with ethanol in healthy male volunteers?
Absolute Event Rate: 62.5% vs 0%
p-value: p=<0.05
Cefotetan administration followed by ethanol ingestion can induce disulfiram-type reactions and hypoprothrombinemia in healthy volunteers.
Kline et al. (1987) conducted an RCT in Healthy volunteers (n=8). Cefotetan vs. 0.9% sodium chloride (placebo) was evaluated on Incidence of facial flushing after ethanol ingestion (p=<0.05). Cefotetan administration followed by ethanol ingestion caused significant facial flushing in 62.5% of healthy male volunteers compared to 0% with placebo, indicating a risk for disulfiram-type reactions.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: