June 1, 1980American Journal of Health-System Pharmacy

Disulfiram-Like Reaction Associated with a Parenteral Cephalosporin

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Why the study?

Does cefoperazone cause a disulfiram-like reaction after alcohol ingestion in healthy volunteers?

Population

12 healthy volunteers in the United States

Design

Case_report

Follow-up

60 hours after receiving the drug

Authors

TFThomas S. FosterCurtin University CRCynthia L. RaehlUNSW Sydney HWHelen WilsonMRC Centre for Reproductive Health

Discussion

Member takes

Implication

Cefoperazone may elicit disulfiram-like reaction with delayed alcohol intake; leaves open systematic assessment in volunteers.

Structured PICO

Does cefoperazone cause a disulfiram-like reaction after alcohol ingestion in healthy volunteers?

Population

12 healthy volunteers in the United States

Intervention

Cefoperazone (T-1551) administered in single 1-, 2-, and 3-g doses as a 5% solution by constant infusion over a five-minute period, with one week between doses

Outcome

Disulfiram-like reaction after alcohol ingestionsafety

Cefoperazone administration may cause a disulfiram-like reaction upon subsequent alcohol ingestion.

Cite This Study

Foster et al. (1980) studied this question.

synapsesocial.com/papers/6a952ff2d33c5efb307cf81c https://doi.org/10.1093/ajhp/37.6.858

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Disulfiram-Like Reaction Associated with a Parenteral Cephalosporin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Disulfiram-Like Reaction Associated with a Parenteral Cephalosporin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider