[Biocompatibility and effect on bone formation of a native acellular porcine pericardium: Results of in vitro and in vivo].

Pengcheng You; Y H Liu; X Z Wang; S W Wang; Lin Tang

doi:10.19723/j.issn.1671-167x.2021.04.026

August 18, 2021Open Access

[Biocompatibility and effect on bone formation of a native acellular porcine pericardium: Results of in vitro and in vivo].

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Key Points

To evaluate the biocompatibility, structural properties, and bone regeneration efficacy of a native acellular porcine pericardium membrane.
Tested native acellular porcine pericardium (APP) in vitro and in vivo within a canine alveolar ridge preservation model against a membrane group and an untreated blank group.
Conducted micro-computed tomography and hematoxylin-eosin histological analysis at 4 and 12 weeks.
Acellular porcine pericardium exhibited favorable biocompatibility and maintained an intact three-dimensional structure.
In the canine model, APP functioned effectively as a barrier membrane, significantly promoting sub-membrane bone regeneration and reducing buccal crest resorption.

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Implication

Demonstrates that acellular porcine pericardium enhances bone formation and reduces crest resorption in a canine model, indicating potential as a regenerative barrier membrane.

Abstract

OBJECTIVE: . METHODS: membrane (BG group) and natural healing (blank group). Micro-CT and hematoxylin-eosin (HE) were performed after 4 and 12 weeks. CONCLUSION: APP showed considerable biocompatibility and three-dimentional structure. Performing well as a barrier membrane in the dog alveolar ridge preservation model, APP significantly promoted bone regeneration below it and reduced buccal crest resorption. On the basis of this study, APP is a potential osteoconductive and osteoinductive biomaterial.

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You et al. (2021) studied this question.

synapsesocial.com/papers/6a9bf1f41d14805efe68ec61 https://doi.org/10.19723/j.issn.1671-167x.2021.04.026

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[Biocompatibility and effect on bone formation of a native acellular porcine pericardium: Results of in vitro and in vivo].

Key Points

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Implication

Abstract

Discussion

Cite This Study

[Biocompatibility and effect on bone formation of a native acellular porcine pericardium: Results of in vitro and in vivo].

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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