Key result
The ADIPOQ 276GT genotype was not significantly associated with hypertension risk but was linked to higher circulating adiponectin (WMD 0.72 μg/mL; P=0.038) and systolic blood pressure.
Why the study?
Are ADIPOQ T45G and G276T polymorphisms associated with hypertension risk and changes in circulating adiponectin and blood pressure?
Meta-Analysis (n=8,479)
Are ADIPOQ T45G and G276T polymorphisms associated with hypertension risk and changes in circulating adiponectin and blood pressure?
Mean Difference: 0.72 (95% CI 0.04–1.41)
p-value: p=0.038
While ADIPOQ T45G and G276T polymorphisms are not significantly associated with hypertension risk overall, the heterozygous G276T mutation is linked to increased circulating adiponectin and blood pressure, particularly in hypertensive patients.
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ADIPOQ polymorphisms confer no hypertension risk; leaves open G276T heterozygote associations with higher adiponectin and blood pressure in observational data.
Wu et al. (2017) conducted a meta-analysis in Hypertension (n=8,479). ADIPOQ T45G and G276T polymorphisms vs. Other genotypes was evaluated on Circulating adiponectin levels for 276GT genotype (WMD 0.72, 95% CI 0.04 to 1.41, p=0.038). The ADIPOQ 276GT genotype was not significantly associated with hypertension risk but was linked to higher circulating adiponectin (WMD 0.72 μg/mL; P=0.038) and systolic blood pressure.
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