Key result
Opioid-free anesthesia during bariatric surgery did not significantly alter the time to first postoperative opioid rescue compared to opioid-based anesthesia (HR 1.23).
Cohort (n=206)
No
Hazard Ratio: 1.23 (95% CI 0.85–1.79)
Absolute Event Rate: 39% vs 46%
p-value: p=0.26
OFA showed comparable postoperative opioid use to OBA under ERAS; leaves open efficacy and safety in prospective randomized bariatric trials.
Retrospective cohort study. Data was collected from medical records from June 2018 to September 2019 for consecutive patients aged 18 and older undergoing elective laparoscopic sleeve gastrectomy for obesity. A standardized ERAS pathway for bariatric surgery was utilized in all study patients. For anesthetic maintenance, the OFA group (n = 46) received propofol combined with dexmedetomidine, lidocaine, and/or ketamine by intravenous infusion. In the opioid-based anesthesia (OBA) group (n = 160), a volatile agent or propofol infusion and opioid were used.
No takes yet. Share an insight, caveat, or question.
Aronsohn et al. (2021) conducted a cohort in Obesity undergoing elective laparoscopic sleeve gastrectomy (n=206). Opioid-free anesthesia (OFA) vs. Opioid-based anesthesia (OBA) was evaluated on Time to administration of first postoperative opioid rescue dose (minutes) (HR 1.23, 95% CI 0.85-1.79, p=0.26). Opioid-free anesthesia during bariatric surgery did not significantly alter the time to first postoperative opioid rescue compared to opioid-based anesthesia (HR 1.23).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: