What question did this study set out to answer?

To evaluate the long-term risk for colorectal cancer incidence and mortality following a single high-quality versus low-quality negative screening colonoscopy.

May 25, 2020Annals of Internal Medicine

Long-Term Colorectal Cancer Incidence and Mortality After a Single Negative Screening Colonoscopy

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Authors

NPNastazja PilonisNational Institute of Oncology MBMarek BugajskiUniversity of Oslo PWPaulina WieszczyOslo University Hospital

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Implication

Observational study finds a negative screening colonoscopy cuts cancer risk and mortality for up to 17 years in average-risk adults, indicating high-quality exams offer durable protection.

Key Points

To evaluate the long-term risk for colorectal cancer incidence and mortality following a single high-quality versus low-quality negative screening colonoscopy.
Observational study of N=165,887 average-risk participants aged 50 to 66 years enrolled in the Polish Colonoscopy Screening Program who had a single negative colonoscopy, followed for up to 17.4 years.
Procedures were categorized as high quality if they were complete, had adequate bowel preparation, and were performed by endoscopists with an adenoma detection rate of 20% or greater.
Primary outcomes were standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs) for colorectal cancer, compared to the general population.
Colorectal cancer incidence was 72% lower (SIR 0.28, 95% CI 0.25 to 0.30) and mortality was 81% lower (SMR 0.19, 95% CI 0.16 to 0.21) than in the general population across follow-up.
High-quality colonoscopy conferred 2-fold lower incidence (SIR 0.16, 95% CI 0.13 to 0.20) and mortality (SMR 0.10, 95% CI 0.06 to 0.14) relative to low-quality examinations (SIR 0.32, 95% CI 0.29 to 0.35; SMR 0.22, 95% CI 0.18 to 0.25).
Multivariable hazard ratios for high- versus low-quality colonoscopy were 0.55 (95% CI, 0.35 to 0.86) for years 0–5, 0.54 (95% CI, 0.38 to 0.77) for years 5.1–10, and 0.46 (95% CI, 0.25 to 0.86) for years 10–17.4.

Cite This Study

Pilonis et al. (2020) studied this question.

synapsesocial.com/papers/6a9bf2ed5d5f5594bd68ec4c https://doi.org/10.7326/m19-2477

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Implication

Observational study finds a negative screening colonoscopy cuts cancer risk and mortality for up to 17 years in average-risk adults, indicating high-quality exams offer durable protection.

Long-Term Colorectal Cancer Incidence and Mortality After a Single Negative Screening Colonoscopy

Discussion

Member takes

Implication

Key Points

Cite This Study

Long-Term Colorectal Cancer Incidence and Mortality After a Single Negative Screening Colonoscopy

Discussion

Member takes

Implication

Key Points

Cite This Study

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