Key result
The GCKR rs780094 AA genotype was significantly associated with higher triglycerides, lower HDL-C, lower HbA1c, and thinner CIMT (p=0.001) in Japanese men, but not women.
Why the study?
Does the GCKR rs780094 polymorphism associate with metabolic traits and carotid intima-media thickness in Japanese community-dwelling adults?
Cross-Sectional (n=2,491)
Does the GCKR rs780094 polymorphism associate with metabolic traits and carotid intima-media thickness in Japanese community-dwelling adults?
The GCKR rs780094 AA genotype is associated with altered metabolic traits and thinner carotid intima-media thickness in Japanese men, suggesting a sex-specific genetic influence on atherosclerosis risk factors.
BACKGROUND: The glucokinase regulator gene (GCKR) rs780094 has been shown to be strongly associated with some metabolic traits and atherosclerotic parameters, while the association between GCKR rs780094 and carotid intima-media thickness (CIMT) has not been fully investigated in the general population. The associations between the GCKR rs780094 genotype and metabolic traits including CIMT were examined in a Japanese community-dwelling population. METHODS: A total of 2491 Japanese adults (907 men and 1584 women) who participated in a medical screening program for the general population from 29 to 94 years of age during 2008 to 2010 were enrolled. GCKR rs780094 was genotyped by the TaqMan polymerase chain reaction method, and associations with metabolic markers including CIMT were evaluated. RESULTS: GCKR rs780094 AA genotype was significantly associated with higher TG (p<0.001 vs. GG), lower HDL-C (p=0.021 vs. GG), and lower HbA1c(p=0.023 vs. GG). The AA genotype showed significantly thinner CIMT (p=0.001 vs. GX). These associations were seen only in men. CONCLUSIONS: GCKR rs780094 was associated with TG, HDL-C, and HbA1c levels, as well as with CIMT in Japanese community-dwelling men, but not women.
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Murata-Mori et al. (2013) conducted a cross-sectional in General population (n=2,491). GCKR rs780094 AA genotype vs. GG or GX genotype was evaluated on carotid intima-media thickness (CIMT) (p=0.001). The GCKR rs780094 AA genotype was significantly associated with higher triglycerides, lower HDL-C, lower HbA1c, and thinner CIMT (p=0.001) in Japanese men, but not women.
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