Key result
Isoproterenol infusion caused an exaggerated increase in heart rate and plasma cAMP in POTS patients compared to controls, and beta-blockers abolished symptoms in 5 of 7 treated patients.
Why the study?
Do patients with POTS exhibit beta-adrenergic hypersensitivity compared to controls, and does beta-blockade improve their symptoms?
Case-Control (n=20)
Do patients with POTS exhibit beta-adrenergic hypersensitivity compared to controls, and does beta-blockade improve their symptoms?
POTS may be driven by beta-adrenergic hypersensitivity, and beta-blocker therapy appears effective in reducing symptoms and orthostatic tachycardia in these patients.
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Supports beta-adrenergic hypersensitivity hypothesis in POTS; leaves open beta-blocker efficacy pending randomized trials.
Abe et al. (2000) conducted a case-control in Postural orthostatic tachycardia syndrome (POTS) (n=20). Isoproterenol infusion vs. Age-matched controls was evaluated on Heart rate and plasma cyclic AMP (cAMP) level responses. Isoproterenol infusion caused an exaggerated increase in heart rate and plasma cAMP in POTS patients compared to controls, and beta-blockers abolished symptoms in 5 of 7 treated patients.
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