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January 1, 2013Frontiers in Human NeuroscienceOpen Access

Identifying and quantifying main components of physiological noise in functional near infrared spectroscopy on the prefrontal cortex

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Key result

A novel physiological de-noising method based on wavelet coherence analysis identified three main noise processes (respiration, Mayer waves, and local skin blood flow regulation) and significantly improved the sensitivity of fNIRS to cerebral signals.

Population

15 healthy subjects. Data from one subject was excluded, leaving n=14 for analysis.

Design

Other

Authors

EKEvgeniya KirlilnaNYNa YuAJAlexander Jelzow

Discussion

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Overview

May enhance fNIRS signal quality in research; leaves open prospective validation before clinical use.

Structured PICO

P
Population
15 healthy adults (mean age 34.9 years, 33% female) underwent concurrent time-domain fNIRS and peripheral physiology recordings to identify physiological noise contributions.
I
Intervention
Concurrent time-domain fNIRS and peripheral physiology recordings (mean arterial blood pressure, heart rate, skin blood flow, respiration) combined with wavelet coherence analysis (WCA) and GLM-based physiological de-noising.
O
Outcome
Identification of main physiological noise contributions in fNIRS forehead signals and development of a method for physiological de-noising.surrogate

A novel physiological de-noising method using wavelet coherence analysis and concurrent peripheral physiology recordings improves the sensitivity of fNIRS to cerebral signals by removing noise from respiration, Mayer waves, and local skin blood flow.

Limitations

  • Proper statistical analysis of group wavelet coherence is mathematically challenging due to non-linear noise propagation.

Cite This Study

Kirlilna et al. (2013) studied Healthy (n=15). Physiological de-noising method using wavelet coherence analysis and GLM vs. Standard fNIRS analysis without physiological de-noising was evaluated on Identification of physiological noise components and improvement of fNIRS sensitivity to cerebral signals. A novel physiological de-noising method based on wavelet coherence analysis identified three main noise processes (respiration, Mayer waves, and local skin blood flow regulation) and significantly improved the sensitivity of fNIRS to cerebral signals.

synapsesocial.com/papers/6a9bf862c12994f0dcbb063fhttps://doi.org/10.3389/fnhum.2013.00864
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