Key result
Admission hyperglycemia in patients with takotsubo syndrome was associated with a higher prevalence of diabetes (39.3% vs. 14.6%) and predicted long-term prognosis.
Why the study?
Does admission hyperglycemia predict heart failure events and mortality in patients with Takotsubo syndrome?
Does admission hyperglycemia predict heart failure events and mortality in patients with Takotsubo syndrome?
Admission hyperglycemia in Takotsubo syndrome is associated with worse clinical presentation and predicts poorer long-term prognosis.
In a letter in this issue of Diabetes Care , Madias suggests that norepinephrine, as mediator of admission hyperglycemia (AH), is an index of increased underlying sympathetic overactivity and/or diabetes comorbidity in patients with takotsubo syndrome (TTS) (1). Indeed, the 28 patients with AH versus the 48 patients without AH had a higher prevalence of diabetes (39.3% vs. 14.6%) (1,2). Notably, AH was a predictor of long-term prognosis in TTS patients (2). Moreover, the patients with AH showed lower left ventricular ejection fraction on admission and discharge and higher B-type natriuretic peptide and inflammatory markers, with the glucose values correlating with serum norepinephrine levels …
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Paolisso et al. (2021) conducted a letter in Takotsubo syndrome (n=76). Admission hyperglycemia vs. Without admission hyperglycemia was evaluated on Prevalence of diabetes. Admission hyperglycemia in patients with takotsubo syndrome was associated with a higher prevalence of diabetes (39.3% vs. 14.6%) and predicted long-term prognosis.
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