Once-daily Preservative-free Topical Anti-glaucomatous Monotherapy – A Better Approach?

or many years, the mainstay of medical treatment for glaucoma has utilised a variety of topical therapies. Historically, topical medications have been fortified with a variety of agents known as preservatives. Unfortunately, although preservatives are potentially useful, they can also cause an array of adverse effects, impacting on the safety and tolerability of these drugs. The unwanted effects of topical medication preservatives have been identified in both human and animal studies. Here we review the potential advantages of utilising preservative-free (PF) prostaglandin monotherapy as a treatment option for patients with primary open-angle glaucoma. We propose that the use of PF topical anti-glaucomatous monotherapy could improve the management of glaucoma, which is a global cause of visual loss and has a significant impact on healthcare resources.