Key result
Liposomal doxorubicin followed by palliative electron beam radiation therapy resulted in a sustained complete response at 4-year follow-up for a large, unresectable scalp angiosarcoma.
Why the study?
Does liposomal doxorubicin followed by radiation therapy improve tumor response in a patient with unresectable cutaneous angiosarcoma of the scalp?
Case Report (n=1)
Does liposomal doxorubicin followed by radiation therapy improve tumor response in a patient with unresectable cutaneous angiosarcoma of the scalp?
Liposomal doxorubicin followed by palliative-dose radiation therapy may induce a sustained complete response in unresectable cutaneous angiosarcoma of the scalp.
Answers are grounded in this paper and cite their sources.
May merit individualized trial in unresectable scalp angiosarcoma; leaves open confirmation in prospective studies.
Cutaneous angiosarcomas of the head and neck are aggressive cancers with a mean overall survival of 30 months. We add to the literature a case report of a 65-year-old man with a large, >10 cm, unresectable, angiosarcoma of the scalp who was treated with two cycles of liposomal doxorubicin (Caelyx(R)) followed by electron beam radiation therapy (30 Gy in 10 fractions over 2 weeks) who has sustained a complete response with a 4-year follow-up. The dose and fractionation of the radiation therapy in this case was palliative and was not expected to give lasting local control of this lesion. It is therefore possible that either the genetic profile of the tumour conferred radiosensitivity or that the radiation therapy induced a recall phenomenon of the liposomal doxorubicin.
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Holloway et al. (2005) conducted a case report in Cutaneous angiosarcoma of the scalp (n=1). Liposomal doxorubicin and electron beam radiation therapy was evaluated on Tumour response. Liposomal doxorubicin followed by palliative electron beam radiation therapy resulted in a sustained complete response at 4-year follow-up for a large, unresectable scalp angiosarcoma.
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