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September 5, 2026StressOpen Access

Cardiac–brain integration and stress: a mechanistic role for the heartbeat-evoked potential?

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Why the study?

The heartbeat-evoked potential provides a metric of heart-brain integration that may advance the mechanistic understanding of acute and chronic stress responses.

Design

Short communication

Key result

The heartbeat-evoked potential (HEP) is highlighted as a promising neurophysiological marker of heart-brain integration for advancing the understanding of acute and chronic stress responses.

Authors

RVRania-Iman VirjeeSGSarah N. Garfinkel

Discussion

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Overview

HEP may index stress effects on heart-brain coupling; hypothesis-generating for interoception research.

Key Points

  • To review the mechanistic role of the heartbeat-evoked potential (HEP) as an electrophysiological marker of neural interoception and explore its utility in stress research.
  • Synthesized theoretical and empirical literature examining the electrophysiological properties of the heartbeat-evoked potential (HEP).
  • Evaluated the capacity of HEP to index central-peripheral integration during acute and chronic stress states.
  • The heartbeat-evoked potential provides an electrophysiological measure of neural interoception that exceeds the explanatory power of isolated cardiac or central neural signals.
  • Modulations in HEP reflect individual differences in clinical and emotional processing, presenting a viable neurophysiological roadmap for investigating acute and chronic stress responses.

PICO

P
Population
Stress
E
Exposure / Comparator
Heartbeat-evoked potential (HEP)

The heartbeat-evoked potential may serve as a valuable neurophysiological marker for understanding heart-brain integration and the mechanisms underlying acute and chronic stress responses.

Cite This Study

Virjee et al. (2026) conducted a review in Stress. Heartbeat-evoked potential (HEP) was evaluated. The heartbeat-evoked potential (HEP) is highlighted as a promising neurophysiological marker of heart-brain integration for advancing the understanding of acute and chronic stress responses.

synapsesocial.com/papers/6a9c00de6b95aff0620ec805https://doi.org/10.1080/10253890.2026.2727608
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