Key result
Single antiplatelet therapy after drug-coated balloon PCI is associated with similar MACE rates as dual therapy.
Observational (n=1,110)
Absolute Event Rate: 9% vs 10%
p-value: p=0.78
Drug-coated balloons are a complementary technology to drug-eluting stents that allow for abbreviated antithrombotic therapy, particularly useful in high bleeding risk patients and specific lesion types.
Drug choice between paclitaxel- and sirolimus-eluting balloons remains uncertain in PCI; leaves open need for head-to-head trials.
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Caballero et al. (2026) conducted an observational in Coronary artery disease requiring percutaneous coronary intervention (n=1,110). Single antiplatelet therapy (SAPT) vs. Dual antiplatelet therapy (DAPT) was evaluated on MACE (Cardiac death, MI, TLR) at 12 months (p=0.78). Single antiplatelet therapy after drug-coated balloon PCI was associated with similar 12-month MACE rates compared to dual antiplate.
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