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An infant with chronic diarrhea due to suspected generalized disaccharidase insufficiency is described. The clinical condition of the infant improved following the removal of lactose and sucrose from the diet. The fermentative and acidic stool with free lactose and lactic acid also improved. However, the infant was too ill to undergo direct assay of intestinal mucosal tissue for disaccharidase activity or for challenge with offending sugars. Postmortem tissue assay revealed less than 10% of normal activity for lactase, sucrase, maltase, and isomaltase in the intestinal mucosa.
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Clarke et al. (1964) studied this question.
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