Key result
Reduced striatal responses to reward and blunted feedback-related negativity potentials are consistently associated with and predictive of the onset of depressive symptoms in adolescence.
Why the study?
No review had yet consolidated evidence of reward processing deficits in adolescent depression across neuroimaging modalities such as fMRI and EEG.
Are depressive symptoms in adolescents associated with abnormalities in neural processing of reward across neuroimaging modalities?
Population
Currently depressed adolescents and community-based adolescent samples
Design
Review
Authors
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Supports investigation of reward-processing targets in adolescent depression; leaves open clinical translation pending prospective trials.
Are depressive symptoms in adolescents associated with abnormalities in neural processing of reward across neuroimaging modalities?
Adolescent depression is consistently associated with reduced striatal responses and blunted FRN potentials during reward processing, which may also predict the onset of depressive symptoms.
O’Callaghan et al. (2019) conducted a review in Adolescent depression. Abnormalities in neural processing of reward (reduced striatal responses and blunted FRN potentials) was evaluated on Depressive symptoms and onset of depressive symptoms. Reduced striatal responses to reward and blunted feedback-related negativity potentials are consistently associated with and predictive of the onset of depressive symptoms in adolescence.
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