Key result
Pericardiocentesis successfully treated a massive pericardial effusion in a neonate, leading to a diagnosis of transient abnormal myelopoiesis associated with Down syndrome.
Massive pericardial effusion in a neonate without hydrops or sepsis can be an unusual presentation of Down syndrome-associated transient abnormal myelopoiesis and is manageable with pericardiocentesis.
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Supports considering TAM in neonates with unexplained pericardial effusion; hypothesis-generating case leaves broader implications open.
In the absence of hydrops or sepsis, pericardial effusion is a rare occurrence in a neonate. We present the case report of a neonate with massive pericardial effusion managed successfully with pericardiocentesis. Further evaluation revealed an unusual presentation of Down syndrome known as transient abnormal myelopoiesis (TAM).
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Jayaprasad et al. (2015) studied this question. Pericardiocentesis successfully treated a massive pericardial effusion in a neonate, leading to a diagnosis of transient abnormal myelopoiesis associated with Down syndrome.
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