Key result
VEGF-C deficiency in murine models resulted in severely hypoplastic peritruncal vessels and delayed, abnormally positioned coronary artery stems.
VEGF-C and aortic cardiomyocytes play critical sequential roles in guiding the proper development and positioning of coronary artery stems during embryogenesis.
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Hypothesis-generating for anomalous coronary origins; leaves open any clinical relevance pending human studies.
Chen et al. (2014) studied Coronary artery stem development. VEGF-C deficiency was evaluated on Coronary artery stem development and peritruncal vessel growth. VEGF-C deficiency in murine models resulted in severely hypoplastic peritruncal vessels and delayed, abnormally positioned coronary artery stems.
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