Key result
Baseline functional class, 6-minute walk distance, and pericardial effusion were significant predictors of mortality in PAH patients, who demonstrated a 5-year survival rate of 77%.
Cohort (n=70)
No
In a Taiwanese cohort of PAH patients, 5-year survival was 77%, with functional class, 6-minute walk distance, pericardial effusion, and right atrial pressure serving as significant prognostic markers.
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Provides survival benchmarks for PAH in Taiwan; extends Western data but leaves open generalizability and prospective validation.
BACKGROUND: Clinical studies have suggested predictive parameters in mortality risk assessment for pulmonary arterial hypertension (PAH) patients. However, these studies predominantly include Caucasian population; information in Asian population is relatively deficient. In this study, we investigated the long-term survival of PAH patients and the predictors of mortality in our population. METHODS: We prospectively collected 70 patients with PAH at the Chang Gung Memorial Hospital between March 2002 and February 2015. Baseline data including functional class (FC), 6-minute walk distance (6MWD), hematological and biochemical data, echocardiography and cardiac catheterization were obtained before commencing PAH- targeted treatment. The follow-up period for analyses of survivors ended in October 2015. RESULTS: The mean age at diagnosis was 40.7 ± 15.2 years. Mean follow-up period was 4.6 ± 3.4 years, with 1-, 2-, 3-, and 5-year survival rates of 93%, 88%, 84%, and 77%, respectively. The baseline FC was worse in non-survivors than in survivors. More frequent presence of pericardial effusion, higher serum glucose levels, higher estimated systolic pulmonary artery pressure (SPAP) by echocardiography, and higher right atrial pressure (RAP) were found in non-survivors. Higher FC, lower 6MWD, and presence of pericardial effusion were associated with risk of mortality. Patients with worsening FC and increased serum uric acid had an increased risk of mortality during follow-up. CONCLUSIONS: The overall survival remained unsatisfactory in PAH patients. Baseline FC, 6MWD, pericardial effusion, RAP, and a worsening FC and an increased serum uric acid levels during follow-up were significant prognostic parameters.
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Wang et al. (2017) conducted a cohort in Pulmonary Arterial Hypertension (n=70). Clinical, echocardiographic, and biochemical parameters was evaluated on Long-term survival. Baseline functional class, 6-minute walk distance, and pericardial effusion were significant predictors of mortality in PAH patients, who demonstrated a 5-year survival rate of 77%.
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