Synthetic study demonstrates oxyselenocyclization of 2-allylphenols using Oxone, highlighting a safe route to hybrid dihydrobenzofuran selenides.
The reaction between Oxone® and various di(hetero)aryl or alkyl diselenides enables the formation of an electrophilic selenium species in situ capable to induce the oxyselenocyclization of 2‐allylphenols. This versatile and safe protocol was explored to combine two privileged scaffolds into the structure of products: the 2,3‐dihydrobenzofuran core and an organoselenium moiety. Fifteen 2‐[(organoselanyl)methyl]‐2,3‐dihydrobenzofurans were produced, broadening considerably the number of known examples of this hybrid compound. Moreover, preparation of sulfur and tellurium 2,3‐dihydrobenzofurans derivatives was also successfully demonstrated.
No takes yet. Share an insight, caveat, or question.
Hellwig et al. (2021) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: