Metabolites with fast turnover rates and/or unstable metabolites can be captured directly from circulating blood using a new solid-phase microextraction (SPME) device based on a hypodermic needle. Such metabolites are not observed using solvent precipitation and ultrafiltration methods, indicating traditional approaches based on blood withdrawal are not adequately capturing complete metabolome at the time of sampling.
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Vuckovic et al. (2011) studied this question.
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