Key result
Furosemide-induced sodium depletion in rats alters 94 hypothalamic genes and reduces vasopressin and oxytocin.
Why the study?
Furosemide is widely used for oedema and hypertension, but the physiological and molecular changes in the hypothalamic-neurohypophysial system resulting from furosemide-induced sodium depletion needed determination.
Population
Male rats
Comparison
Acute furosemide injection (10 and 30 mg/kg) with low sodium diet and distilled water
Design
Animal experimental study
Follow-up
24 h
Authors
Loading...
Furosemide-induced sodium depletion alters rat hypothalamic-neurohypophysial function; leaves open translation to human diuretic therapy.
Dutra et al. (2020) studied Sodium depletion. Furosemide was evaluated on Physiological and molecular changes in the hypothalamic-neurohypophysial system. Furosemide-induced sodium depletion in male rats significantly altered the expression of 94 genes in the hypothalamic paraventricular nucleus and reduced plasma vasopressin and oxytocin levels.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: