Key result
Hypothyroidism was associated with cardiac autonomic dysfunction, with time domain parameters of short-term HRV (SDRR, RMSSD) yielding good correlation between hypothyroid and normal subjects.
Why the study?
Cardiac autonomic dysfunction is established in hypothyroidism, but the effectiveness of individual time-domain parameters of short-term heart rate variability analysis needed evaluation.
Do time-domain parameters of short-term heart rate variability analysis differ between hypothyroid subjects and normal individuals?
Case-Control (n=50)
No
Do time-domain parameters of short-term heart rate variability analysis differ between hypothyroid subjects and normal individuals?
Time-domain parameters of short-term HRV analysis, specifically SDRR and RMSSD, are effective in assessing cardiac autonomic dysfunction in hypothyroid patients.
HRV time-domain parameters detect autonomic dysfunction in hypothyroidism; leaves open clinical utility and parameter standardization.
Introduction: Heart rate variability analysis is being widely used in the study of endocrine disorders such as hypothyroidism. It is well established that cardiac autonomic dysfunction occurs in hypothyroidism and is also confirmed in this study. Aim: To find out the effectiveness of each time- domain parameters of short- term HRV analysis done in time-domain analysis method. Materials and Methods: 25 Hypothyroid subjects are obtained (study group) from the department of endocrinology and metabolism, govt. Rajaji Hospital attached to Madurai Medical College, Madurai. And 25 normal subjects who are age and sex matched with the study group form the control group. All the persons are free from any other illness. Serum TSH levels are estimated in all the subjects. ECG recording in Lead II is performed in all the subjects using computerized ECG machine enabled with physio-pac software and time domain parameters are obtained by short term HRV analysis method. The results are tabulated and analysed by applying student- t test. Results and Conclusion: Time domain parameters with increasing mathematical complexity (SDRR, RMSSD) yield good correlation between the two study groups.
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Baskar et al. (2018) conducted a case-control in Hypothyroidism (n=50). Hypothyroidism vs. Normal individuals was evaluated on Time-domain parameters of short-term HRV analysis (SDRR, RMSSD). Hypothyroidism was associated with cardiac autonomic dysfunction, with time domain parameters of short-term HRV (SDRR, RMSSD) yielding good correlation between hypothyroid and normal subjects.
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