Key result
Variations in 3D arterial geometry and dynamics contribute to variability in the hemodynamic environment and may play a role in the local progression and epidemiology of coronary artery disease.
Individual and site-specific variations in 3D coronary arterial geometry and dynamics may play a significant role in the hemodynamics and progression of coronary artery disease.
May support geometry-informed CAD risk models; leaves open prospective validation before clinical use.
Geometric parameters and features vary within the vasculature. Furthermore, at any given anatomic site, there are substantial variations in geometry among individuals. These variations can contribute to a corresponding variability in the hemodynamic environment and, to the extent that hemodynamics affects the atherosclerotic process, the progress of vascular disease. Measurements of the geometry and wall morphometry of post-mortem human coronary arteries demonstrate a relationship between these variables that supports the notion that geometric variations can contribute to a corresponding variability in the local rate of progression of arterial disease. The dynamic geometry of the coronary arteries also varies from site to site and among individuals, and this variability too may play a role in the epidemiology of coronary artery disease.
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Morton H. Friedman (2002) conducted a review in Coronary artery disease. Variations in 3D arterial geometry and dynamics was evaluated on Progression of arterial disease. Variations in 3D arterial geometry and dynamics contribute to variability in the hemodynamic environment and may play a role in the local progression and epidemiology of coronary artery disease.
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