Key result
Chronic exposure to waste anaesthetic gases linked to altered hepatic and haematological markers.
Why the study?
Health workers face potential health risks from exposure to waste anaesthetic gas (WAG) in treatment or operating rooms, prompting evaluation of hepatic and haematological alterations from chronic exposure.
Does chronic exposure to waste anaesthetic gases alter hepatic and haematological parameters in hospital staff?
Observational
Does chronic exposure to waste anaesthetic gases alter hepatic and haematological parameters in hospital staff?
Chronic occupational exposure to waste anaesthetic gases like Sevoflurane is associated with alterations in liver and blood parameters among hospital staff.
May warrant monitoring of hepatic and haematological indices in exposed staff; hypothesis-generating and requires prospective confirmation.
A significant health risk exists within a section of health workers that are exposed to anaesthetic gas and vapours, found in the atmosphere of treatment or operating rooms. These compounds are classified as waste anaesthetic gases (WAG). The present study aimed at identifying alterations in hepatic and haematological parameters occurring as a result of chronic exposure to WAG potentially affecting the health of team members working in hospitals. Therefore, operating room operatives, vulnerable to long-standing WAG exposure, were recruited for this study. Sevoflurane anaesthesia metabolites (inorganic fluoride and hexafluoroisopropanol (HFIP)), haematological indices and liver toxicity markers (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transferase and osteopontin) were measured. The collected results showed increased plasma inorganic fluoride, HFIP and liver toxicity markers, as well as disturbances in haematological parameters. In conclusion, exposure to halogenated inhalational anaesthetics, in general, and Sevoflurane, in particular, induces alterations in hepatic markers and haematological indices.
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Emara et al. (2020) conducted an observational in Exposure to waste anaesthetic gases. Waste anaesthetic gases (WAG) was evaluated on Alterations in hepatic and haematological parameters (including inorganic fluoride, HFIP, and liver toxicity markers). Chronic exposure to waste anaesthetic gases, particularly Sevoflurane, induced alterations in hepatic markers and haematological indices among operating room operatives.
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