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Glucose-sensitive hydrogels that have three-dimensional network structure can respond to the glucose, which arouses great interest in biochemistry and biomedical. As a glucose sensitive group, Benzene boric acid has the advantages of good stability, low toxicity and no immune rejection. In this study, synthetic 3-acrylamidophenylboronic acid (AAPBA) with N-isopropylacrylamide (NIPAM) were used to fabricate glucose-responsive hydrogels via free radical polymerization in aqueous media. Several key factors such as polymer compositions and polymer concentrations have been investigated to sensitivity of the hydrogels. These polymers can respond in the presence of glucose, and the monomer ratio has a significant influence on the response behavior of hydrogels. Therefore, it has potential applications in the field of insulin-controlled drug delivery system and biosensor.
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Yuan et al. (2018) studied this question.
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