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Does hydrogenobyrinic acid 1 play a significant role in the biosynthesis of vitamin B12? The cobalt-free analogue 1 of the vitamin-B12 precursor cobyrinic acid cannot be converted into cobyrinic acid with enzyme preparations which catalyze the incorporation of cobalt. Hence, the answer to the above question is no, and the problem of when the cobalt ion becomes incorporated in the formation of vitamin B12 remains unsolved (R H).
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Podschun et al. (1985) studied this question.
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