Key result
Neuregulin-1 plays a crucial role in embryonic heart development and adult cardiovascular homeostasis, and recombinant neuregulin isoforms show potential for treating certain cardiac diseases.
Neuregulin-1 is essential for cardiovascular development and cardioprotection, highlighting its potential as a therapeutic target for heart failure and ischemic heart disease, despite risks of off-target proliferation.
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Neuregulin-1 may support targeted therapy development in heart failure; leaves open clinical safety and efficacy in randomized trials.
Smiljić et al. (2016) conducted a review in Cardiovascular diseases and heart development. Neuregulin-1 was evaluated. Neuregulin-1 plays a crucial role in embryonic heart development and adult cardiovascular homeostasis, and recombinant neuregulin isoforms show potential for treating certain cardiac diseases.
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